Not known Factual Statements About naga26
Not known Factual Statements About naga26
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-acetyl by-product. This result's consistent with the development or collapse with the tetrahedral intermediate as the speed restricting action during the catalytic mechanism of NagA.
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m isn't confined through the association fee frequent for that formation on the NagA-substrate sophisticated. These final results (together with the improved rate of reaction of compound six relative to compound 1) are only in keeping with the conclusion that NagA is proscribed by either the formation or breakdown with the tetrahedral intermediate.
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a could be the acid dissociation constant. pH-charge profiles that showed the loss of catalytic exercise at superior and small values of pH ended up suit to equation 4, the place K
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-trifluoroacetyl substituted substrate is hydrolyzed 26 occasions faster compared to the purely natural substrate but the N
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